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Correction: Reduced opioids after total joint replacement surgery (REPAIRS): a pilot randomized controlled trial.

Journal of orthopaedic surgery and research·2025
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Reduced opioids after total joint replacement surgery (REPAIRS): a pilot randomized controlled trial.

Zhiwei Yang1,

  • 1Institute for Musculoskeletal Health, Level 10N, King George V Building, Missenden Road, Sydney, PO Box M179, NSW, 2050, Australia. zhiwei.yang@sydney.edu.au.

Journal of Orthopaedic Surgery and Research
|August 21, 2025
PubMed
Summary

This pilot study found a reduced opioid regimen after hip or knee replacement surgery to be feasible and acceptable. A larger trial can now assess its effectiveness in managing pain while minimizing side effects.

Keywords:
AcceptabilityFeasibilityOpioidsTotal hip replacementTotal knee replacement

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Area of Science:

  • Orthopedic Surgery
  • Pain Management
  • Clinical Trials

Background:

  • Opioid analgesics are standard for post-total knee and hip replacement pain.
  • Optimal opioid discharge dosage for pain control versus adverse events remains unclear.
  • This study assessed a reduced opioid regimen's feasibility and acceptability.

Purpose of the Study:

  • To determine the acceptability and feasibility of a trial comparing reduced and standard opioid discharge regimens.
  • To evaluate pain management and adverse events associated with different opioid dosages.
  • To inform the design of a full-scale trial on opioid use post-arthroplasty.

Main Methods:

  • Pilot randomized controlled trial at a Sydney metropolitan hospital.
  • Participants received standard non-opioid analgesics plus either standard (20 tablets) or reduced (10 tablets) oxycodone discharge.
  • Primary outcomes included recruitment rates, follow-up completion, and acceptability via surveys and interviews; adverse events were monitored.

Main Results:

  • Recruitment rate was 21% (53/254 screened); 93% completed follow-ups.
  • Trial intervention acceptability was rated neutrally to acceptably (3.6/5) by participants.
  • Few adverse events were reported, most commonly constipation; clinicians and patients supported the trial design.

Conclusions:

  • This pilot trial demonstrates the feasibility and acceptability of a full-scale study.
  • A larger trial can now provide evidence on the comparative effectiveness of reduced opioid regimens.
  • Findings support further investigation into optimizing opioid prescribing after joint replacement surgery.