Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity

Many new cyclized pyran systems with a potential anti-cancer activity were 13 designed and prepared. Pyran systems showed high reactivity to various chemical 14 reagents. 24 products of the prepared compounds were chosen and tested in (mM) as 15 respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were 16 the widely effective compounds against the three cancer cell lines including A-549 17 (Lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (Gastric cancer) 18 compared to the standard reference control foretinib.