Related Experiment Video
Updated: Sep 10, 2025

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
A Study of Expert Perspectives on the Administration of Cefpodoxime and its Combinations in Respiratory Infections:
Ashish Jain1, Hemant Thacker2, Jaskaran Singh3
1Associate Director and Head of the Department, Department of Respiratory Medicine, Max Super Speciality Hospital, Delhi, India.
Background:
The growing threat of antimicrobial resistance (AMR) poses a significant challenge globally in the treatment of respiratory tract infections (RTIs). The PERCEPT survey aimed to capture Indian healthcare practitioners' (HCPs) perspectives on the prevalence of RTIs, AMR patterns, AMR diagnosis, and clinical evaluation of cefpodoxime and its combination with clavulanic acid in managing RTIs.
Materials And Methods:
A structured questionnaire was used to conduct a cross-sectional survey among 1,000 healthcare professionals (HCPs) who manage RTIs in Indian adults and children, with 842 participants responding. The collected data were compiled and thoroughly analyzed.
Results:
Most HCPs reported RTIs in 26-50% of adult and pediatric patients, with the most common RTIs including pharyngitis/tonsillitis, bronchitis, and common cold. Streptococcus pneumoniae and Staphylococcus aureus were reported as the prevalent antibiotic-resistant microorganisms causing upper respiratory tract infections (URTIs) and lower respiratory tract infection (LRTIs). Antibiotic susceptibility testing (AST) is a common method to detect AMR in patients with RTIs. Among antibiotics, amoxicillin was the most common linked with resistance to microorganisms causing RTIs. Cefpodoxime alone or in combination with clavulanic acid was the most preferred drug for managing RTIs due to its high efficacy, broad-spectrum activity, safety, and better tolerability.
Conclusion:
Indian practitioners find cefpodoxime monotherapy and its combination with clavulanic acid effective in managing RTIs compared to earlier-generation cephalosporins and amoxicillin.
More Related Videos
11:15Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
09:26Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Cystic Fibrosis: Management
Sinus disease and chronic...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...