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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
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Diagnosis of Cardiac Amyloidosis in South Asia: Need for a Collaborative Approach from Researchers and Clinicians

Shreya Ghosh1, Dibbendhu Khanra2, Chayanika Kala3

  • 1Department of Biological Sciences and Bioengineering; Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, Uttar Pradesh, India; Department of Chemistry and Chemical Biology Northeastern University, Boston, Massachusetts, United States, Corresponding Author.

The Journal of the Association of Physicians of India
|August 21, 2025
PubMed

Insights

Accurate diagnosis of cardiac amyloidosis (CA) is now more possible due to new methods. Early CA detection is crucial for South Asian patients, especially during the COVID-19 pandemic, to improve outcomes.

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Public Health

Background:

  • Cardiac amyloidosis (CA) diagnosis has improved with recent advancements.
  • Cardiovascular diseases are rising in South Asia, with many undiagnosed CA cases.
  • Amyloidosis patients are susceptible to SARS-CoV-2, necessitating prompt CA diagnosis and management during the COVID-19 pandemic.

Purpose of the Study:

  • To review recent diagnostic approaches for cardiac amyloidosis (CA).
  • To outline adapted treatment options for CA.
  • To present future initiatives for diagnosing CA in the South Asian population.

Main Methods:

  • Literature review of recent diagnostic and treatment strategies for CA.
  • Analysis of CA prevalence and diagnostic challenges in South Asia.
  • Discussion of future diagnostic initiatives.

Main Results:

  • New diagnostic tools enhance the accuracy of CA detection.
  • The review covers current and future strategies for CA diagnosis and management.
  • Collaborative adoption of these approaches can improve CA diagnosis in India and South Asia.

Conclusions:

  • Enhanced diagnostic capabilities offer improved accuracy for cardiac amyloidosis.
  • Prompt diagnosis and management of CA are vital, particularly in the context of rising cardiovascular diseases and SARS-CoV-2 susceptibility.
  • Future initiatives and collaborative efforts are essential for accurate CA diagnosis in the South Asian population.

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