Related Experiment Video
Updated: Sep 10, 2025
08:13
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
6.5K
Unmet Needs in Hemophilia: A Narrative Review
Rabindra K Jena1, Tuphan K Dolai2, Jina Bhattacharyya3
1Professor and Bone Marrow Transplant Physician, Department of Clinical Hematology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India, Corresponding Author, Orcid: https://orcid.org/0000-0001-9525-3016.
The Journal of the Association of Physicians of India
|August 21, 2025
Summary
This review highlights unmet needs in hemophilia management, including inadequate bleed protection and the burden of hemophilic arthropathy. Addressing these is key to improving patient quality of life and outcomes.
Area of Science:
- Hematology
- Genetics
- Public Health
Background:
- Hemophilia is a rare genetic bleeding disorder requiring lifelong, comprehensive management.
- Current treatments aim to improve life expectancy and quality of life (QoL).
- Despite progress, significant challenges remain in hemophilia care.
Purpose of the Study:
- To review the current state of hemophilia management.
- To identify and analyze unmet clinical needs in hemophilia.
- To emphasize the impact of hemophilia on patients' lives.
Main Methods:
- Literature review of hemophilia management strategies.
- Analysis of current treatment options and their limitations.
- Assessment of patient-reported outcomes and quality of life.
Main Results:
- Suboptimal bleed protection with existing prophylactic therapies.
- Development of inhibitory alloantibodies complicates treatment.
- Hemophilic arthropathy (HA) leads to joint damage and disability.
- Significant physical and psychological burden impacts education, employment, and QoL.
Conclusions:
- Innovative therapies are needed to improve bleed control.
- Addressing alloantibody development is critical.
- Individualized treatment strategies and improved access to care are essential.
- Reducing the burden of hemophilia, especially in high-prevalence regions like India, requires focused interventions.
Related Concept Videos
01:24Disorders of Hemostasis
1.2K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.2K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
893
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
893
01:30Venous Thrombosis IV: Nursing Management
23
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
23
01:29Venous Thrombosis III: Interprofessional Care
22
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
01:05Introduction to Hemostasis
8.9K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.9K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
9.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
9.2K