A Masquerading Case of Cryptococcus neoformans

Cryptococcus is a common infection in immunocompromised hosts. Ordinarily, Cryptococcus tends to have a strong tropism for the central nervous system (CNS). Other organs or systems of the body are less commonly involved. Here we describe a patient who had cutaneous tropism. The predominant presentation of this patient was painful thigh lesions. This case highlights several practical difficulties in identifying such infections, and also demonstrates the clinical utility of some of the commonly followed practices in infectious diseases and medicine.