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Updated: Sep 10, 2025

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Use of Target Tetra with an understanding of its novel structure
Naoki Omura1, Yusuke Kinoshita1, Takumi Hoshimaru1
1Department of Neurosurgery, Tesseikai Neurosurgery Hospital, Shijonawate, Japan.
Background:
Coil embolization for cerebral aneurysms is an important technique and is not likely to be replaced in the foreseeable future. Recently, the Target Tetra detachable coil (TTDC) has become available, thereby raising expectations for a safer embolization in small aneurysms. Based on our experience, we report the behavioral characteristics and effective utilization of TTDCs.
Methods:
We analyzed 28 patients who underwent surgery using the TTDC for intracranial aneurysms between December 2023 and November 2024.
Results:
Five cases were treated using the TTDC only. In four of five cases, the aneurysm height was <3 mm. In terms of complications, intraprocedural rupture occurred in two cases and thrombosis in two. None of the patients presented with delayed hemorrhage during the follow-up period.
Conclusion:
The TTDC coils cluster at the tip of the microcatheter. Thus, effective embolization can be achieved by filling from the deeper available space. Based on the behavioral characteristics of TTDCs, it is not only beneficial as a finishing coil but also plays a role in filling. We believe that TTDCs may be a useful option for embolizing small aneurysms, including ruptured ones that were previously challenging to treat, and cases in which microcatheter stability are compromised.
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