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Study on Risk Factors and Treatment Strategies for Deep Vein Thrombosis in Patients with Multiple Myeloma

Yifei Guo1, Lixiang Yan1, Xi Yang1

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300380, People's Republic of China.

Cancer Management and Research
|August 21, 2025
PubMed

Insights

Multiple myeloma (MM) patients face a high risk of deep vein thrombosis (DVT) due to the disease and its treatments. Understanding risk factors and prevention is crucial for improving patient outcomes and quality of life.

Area of Science:

  • Hematology
  • Oncology
  • Vascular Medicine

Background:

  • Multiple myeloma (MM) is a plasma cell malignancy with increasing incidence.
  • Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common complication in MM patients.
  • The procoagulant state, inflammation, and therapies in MM contribute to elevated DVT risk, though mechanisms require further elucidation.

Purpose of the Study:

  • To analyze the relationship between risk factors for DVT and MM.
  • To explore current diagnostic methods and risk assessment tools for DVT in MM.
  • To review personalized preventive treatment strategies and propose future research directions.

Main Methods:

  • Literature review and analysis of relevant studies.
  • Examination of the interplay between MM pathophysiology and thrombogenesis.
  • Assessment of diagnostic and therapeutic approaches for DVT in MM.

Main Results:

  • MM, inflammation, and treatments significantly increase DVT incidence.
  • DVT negatively impacts survival, necessitates treatment changes, and reduces quality of life.
  • Current understanding of exact mechanisms linking MM and DVT requires further investigation.

Conclusions:

  • Enhanced understanding of MM and DVT is vital for clinical practice.
  • Personalized prevention and management strategies are essential for MM patients at risk of DVT.
  • Further research is needed to fully elucidate the mechanisms and optimize DVT prevention in MM.
Keywords:
deep vein thrombosismultiple myelomaprevention and treatment strategiesrisk assessmentrisk factors

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