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Updated: Sep 10, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

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Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy

JunFei Liu1, XiaoPing Qian1, TaoXia Wang1

  • 1Affiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, China.

Journal of Medical Biochemistry
|August 21, 2025
PubMed

Insights

Elevated uric acid (UA) and C1q levels are independent risk factors for cardiovascular disease (CVD) in diabetic nephropathy (DN) patients. Higher levels of UA and C1q correlate with increased CVD risk, aiding in patient evaluation.

Area of Science:

  • Nephrology
  • Cardiology
  • Diabetology

Background:

  • Diabetic nephropathy (DN) is a common complication of diabetes mellitus, increasing cardiovascular disease (CVD) risk as renal dysfunction progresses.
  • Effective management of DN and CVD requires identifying and addressing shared risk factors.

Purpose of the Study:

  • To identify independent risk factors for cardiovascular disease (CVD) in patients with diabetic nephropathy (DN).
  • To investigate the relationship between uric acid (UA), C1q, C-reactive protein (CRP), and CVD risk in DN patients.
  • To evaluate the predictive efficacy of UA and C1q for CVD in DN.

Main Methods:

  • A cross-sectional study involving 98 DN patients, divided into DN (n=58) and DN/CVD (n=40) groups.
  • Univariate and multivariate Logistic regression analyses were used to identify independent risk factors for CVD.
  • Regression modeling and ROC curve analysis assessed the relationship between UA, C1q, CRP, and CVD risk.

Main Results:

  • Elevated uric acid (UA) and C1q were identified as independent risk factors for CVD in DN patients.
  • A linear association was observed between UA/C1q levels and the risk of CVD.
  • C1q demonstrated superior predictive performance for CVD compared to UA and CRP.

Conclusions:

  • Increasing UA and C1q levels significantly elevate CVD risk in DN patients.
  • UA and C1q are valuable indicators for assessing CVD development and progression in DN.
  • These markers offer supportive evaluation value for the clinical condition of DN patients.
Abstract

Keywords:
cardiovascular eventscomplement pathwaycomplicationsdiabetic nephropathy

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