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Clinical comparison of simultaneous integrated and sequential boost IMRT of tumor bed after breast conserving surgery
Minghai Shao1, Caiping Jiang1, Yunxiang Yao1
1Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Department of Radiation Oncology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China.
Background:
To explore the clinical effect compare between the simultaneous-integrated boost and sequential-boost intensity modulated radiotherapy in early breast cancer patients after breast conserving surgery.
Methodology:
According to the different postoperative radiotherapy methods, 66 early breast cancer patients after breast-conserving surgery were divided into two groups, 34 in the simultaneous-integrated boost group and 32 in the sequential-boost intensity group. Adverse reactions, cosmetic effects, local recurrence rate, progression-free survival and overall survival rates were compared.
Results:
No statistical significance in the incidence of acute skin reaction, advanced skin reaction, myelosuppression, radiation pneumonia and other adverse reactions between two groups were observed. The fine rate of simultaneous-integrated boost group was slightly better than the sequential-boost intensity group. And the follow-up rate of the two groups was 100%. The progression-free survival rate of the simultaneous-integrated boost group and the sequential-boost intensity group were 100% and 96.88%, respectively; The overall survival rates of the two groups were all 100%; One patient in the sequential-boost intensity group had recurrence (3.13%), while none in the simultaneous-integrated boost group. No significant difference in local recurrence rate, progression-free survival and overall survival rates in the two groups were found.
Conclusion:
Simultaneous-integrated boost ensures breast appearance and survival without added radiotherapy side effects vs sequential-boost intensity.
