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Growth, biochemical and haematological status of very low birth weight premature infants
Insights
Alprem formula supports growth in very low birth weight premature infants. However, early sodium/potassium and later calcium/phosphate supplementation may be required for optimal infant nutrition.
Area of Science:
- Neonatal nutrition
- Pediatric gastroenterology
- Infant development
Background:
- Premature infants, especially those with very low birth weight, have unique nutritional needs.
- Alprem is a specialized infant formula for premature infants.
- Ensuring adequate nutrient intake is critical for growth and development in this vulnerable population.
Purpose of the Study:
- To evaluate the efficacy of Alprem formula in supporting the growth of very low birth weight premature infants.
- To assess the adequacy of nutrient supply, specifically electrolytes and minerals, during the initial 10 weeks of life.
Main Methods:
- A cohort of very low birth weight premature infants (less than 1500 g, less than 33 weeks gestation) was fed Alprem formula.
- Infant weight, serum electrolyte levels (sodium, potassium), calcium, phosphate, and alkaline phosphatase were monitored.
- Nutrient intake from the formula was compared against estimated infant requirements.
Main Results:
- Infants experienced initial weight loss, followed by satisfactory and steady weight gain.
- Sodium and potassium intake from Alprem were insufficient during the initial feeding period.
- Serum calcium and phosphate levels decreased in the later study period, with elevated alkaline phosphatase.
Conclusions:
- Alprem formula can support adequate growth in small premature infants.
- Supplementation of sodium and potassium is recommended in the early phase of feeding.
- Calcium and phosphate supplementation may be necessary in the later stages of Alprem feeding for these infants.
Abstract:
Very low birth weight (less than 1500 g) premature (less than 33/52) infants were studied while fed on Alprem for the first 10 weeks of life. After initial weight loss due to inadequate intake, weight gain was satisfactory and steady. The need for sodium and potassium exceeded the amount supplied in the milk only in the initial period. However, the serum calcium and phosphate levels were slightly decreased especially in the later period of the study, accompanied by marked elevation in alkaline phosphatase values. Alprem appears to be able to sustain adequate growth in small prematures though early sodium and potassium, and late calcium and phosphate supplements seem necessary.