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Symptom Burden and Intervention Outcomes in Idiopathic Normal Pressure Hydrocephalus: A Multicenter Retrospective
Joshua Amaya1, Zachary D Griffin1, Curran Reddy1
1Graduate Medical Education, Baylor Scott & White All Saints Medical Center, Fort Worth, USA.
Cureus
|August 21, 2025
Summary
Normal pressure hydrocephalus (NPH) is a reversible dementia cause. More symptoms increased treatment likelihood, but improvement rates were similar regardless of symptom count, indicating potential undertreatment and gender disparities.
Area of Science:
- Neurology
- Neurosurgery
- Geriatrics
Background:
- Normal pressure hydrocephalus (NPH) is a treatable dementia cause.
- NPH presents with gait disturbance, urinary incontinence, and cognitive decline.
- Radiologic findings suggestive of NPH often exist despite lack of treatment.
Purpose of the Study:
- Correlate radiographic NPH findings with clinical symptoms.
- Investigate if symptom count predicts intervention and improvement.
- Assess gender disparities in NPH treatment.
Main Methods:
- Multicenter retrospective chart review (2019-2023).
- Included patients with radiologic NPH evidence.
- Recorded symptom burden, intervention rates, and outcomes.
Main Results:
- 82.3% of patients had at least one NPH symptom.
- Intervention rates and treatment response increased with symptom count.
- Men were more likely to receive treatment; improvement rates were similar across symptom counts.
Conclusions:
- A significant proportion of NPH patients may be undertreated.
- Symptom burden and gender influence treatment decisions.
- Further investigation into NPH treatment disparities is warranted.
