Correlation of Fibrinogen-Albumin Ratio With Gensini Score in ST-Segment Elevation Myocardial Infarction

Introduction ST-segment elevation myocardial infarction (STEMI) is a severe form of coronary artery disease (CAD) often associated with systemic inflammation. The fibrinogen-albumin ratio (FAR) has been proposed as a novel inflammatory marker with potential prognostic value. The Gensini score, derived from coronary angiography, quantifies the severity of CAD. This study aimed to assess the correlation between FAR and Gensini score in STEMI patients. Materials and methods A cross-sectional observational study was conducted at a tertiary care center in Karnataka, India, from May 2023 to December 2024. Seventy patients with a clinical diagnosis of STEMI were enrolled. Clinical evaluation, blood tests (including fibrinogen and albumin levels), echocardiography, and coronary angiography were performed. FAR was calculated by dividing fibrinogen (g/L) by albumin (g/L), and Gensini scores were computed to assess CAD severity. Statistical analysis included Pearson's correlation and the chi-squared test. Results The study population comprised mostly men (47, 67.14%) and individuals aged over 60 years (40, 57.14%). Single and double vessel disease were each present in 24 (34.3%) patients. FAR >0.1 was seen in 37 (52.86%). A significant association was found between Gensini score and the extent of vessel disease (p=0.0001); however, FAR did not show a statistically significant correlation with Gensini score (r=-0.002; p=0.989). FAR also lacked a significant association with heart failure types. Conclusion FAR may have limited utility in predicting angiographic severity in patients with STEMI. While it remains a simple and economical inflammatory marker, its prognostic relevance in acute coronary events appears uncertain. Further research with larger cohorts is warranted to validate its clinical applicability.