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Small-Cell Lung Cancer Presenting as Hypercalcemia
Sandra Abadir1, Ariel Ahl1, Harendra Ipalawatte1
1Internal Medicine, Los Robles Regional Medical Center, Thousand Oaks, USA.
Cureus
|August 21, 2025
Summary
Hypercalcemia is rare in small-cell lung carcinoma (SCLC) but indicates a poor prognosis. This case highlights refractory hypercalcemia in SCLC, managed with bisphosphonates and palliative care.
Area of Science:
- Oncology
- Endocrinology
- Internal Medicine
Background:
- Hypercalcemia of malignancy is a frequent complication in advanced cancers, but notably rare in small-cell lung carcinoma (SCLC).
- Patients with SCLC typically maintain normal parathyroid hormone levels despite elevated calcium, making hypercalcemia an unusual presentation.

