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In utero exposure to extreme heat increases neonatal mortality
Tenghui Wang1, Jiafu An2, Bin Chen3,4
1Department of Finance, Faculty of Business, Lingnan University, Hong Kong SAR 999077, China.
PNAS Nexus
|August 21, 2025
Summary
Extreme heat exposure during pregnancy increases neonatal deaths in Sub-Saharan Africa. Vulnerable mothers and infants face higher risks, necessitating targeted climate change adaptation strategies.
Area of Science:
- Environmental Health
- Climate Change Impacts
- Maternal and Child Health
Background:
- Sub-Saharan Africa (SSA) faces the world's highest neonatal mortality rates.
- Climate change is increasing extreme heat events in SSA, impacting vulnerable populations.
- The link between in-utero heat exposure and neonatal mortality in SSA is not well understood.
Purpose of the Study:
- To investigate the association between extreme heat exposure during pregnancy and neonatal mortality in SSA.
- To quantify the impact of heat exposure, considering humidity, on neonatal deaths.
- To identify socioeconomic factors influencing vulnerability to heat exposure.
Main Methods:
- Utilized granular data on extreme heat and birth records from 33 SSA countries.
- Employed nationally representative, repeated cross-sectional Demographic and Health Surveys.
- Applied a heat measure accounting for both temperature and humidity.
Main Results:
- A cumulative 150 °C increase in extreme heat exposure during pregnancy is linked to two additional neonatal deaths per thousand live births.
- Mothers with lower socioeconomic status or limited education experienced more severe negative impacts.
- Reduced prenatal care access may exacerbate the adverse effects of heat exposure.
Conclusions:
- In-utero exposure to extreme heat is a significant contributing factor to neonatal mortality in SSA.
- Climate change adaptation strategies must consider the heightened risks for vulnerable pregnant women and newborns.
- Policy interventions should focus on mitigating heat's impact and supporting at-risk populations.

