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Updated: Sep 10, 2025

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
Published on: February 28, 2025
Isolation techniques for gastrointestinal tract defects: Two case reports
Aleksei A Kashintsev1, Roman Vladimirovich Eselevich2, Dmitry Aleksandrovich Surov2
1PANDICA LTD, London WC1N 3ES, United Kingdom. alexey.kashintsev@pandica.com.
Background:
Gastrointestinal (GI) tract injuries and defects form a heterogeneous group of conditions often presenting with fistula formation. Management depends on factors such as defect number, anatomical location, and patient status, requiring a therapy that addresses multiple etiopathogenic factors.
Case Summary:
We present two cases of patients who underwent total gastrectomy for gastric malignancy. A combined therapeutic approach was employed, based on isolating the injury site with local vacuum-assisted closure (VAC) therapy and simultaneous enteral nutrition. This method facilitated successful healing and enabled the identification of previously undetected defects not recognized by conventional diagnostics.
Conclusion:
The combination of injury site isolation, local VAC therapy, and enteral feeding proved to be safe, effective, and easily adaptable to standard surgical practice. This approach may expand surgical options in the treatment of GI tract injuries and defects.
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