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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Rheumatic diseases presenting with young ischemic stroke: Revelations from tertiary center experience.
Hatice Ecem Konak1, Serdar Can Guven1, Ebru Atalar1
1Department of Rheumatology, Ankara Bilkent City Hospital, Ankara, Turkiye.
Northern Clinics of Istanbul
|August 21, 2025
Summary
This study found that rheumatological diseases are a potential cause of early-onset ischemic stroke in young adults. Early rheumatology referral is crucial for accurate diagnosis and preventing recurrent strokes.
Area of Science:
- Rheumatology
- Neurology
- Internal Medicine
Background:
- Ischemic stroke in young adults presents diagnostic challenges.
- Identifying underlying rheumatological causes is critical for effective management.
Purpose of the Study:
- To determine the frequency and clinical features of rheumatological diseases in patients with first-time ischemic stroke.
- To investigate the role of rheumatology in the etiology of early-onset ischemic stroke.
Main Methods:
- Retrospective analysis of patients aged 18-65 with first ischemic stroke.
- Inclusion of patients referred to rheumatology for etiological investigation.
- Data collection included demographics, lab results, imaging, and final diagnoses.
Main Results:
- 115 patients with first ischemic stroke were identified; 70 had early-onset stroke.
- Diagnosed rheumatological conditions included lupus with secondary antiphospholipid syndrome (APS), primary APS, primary Sjögren's syndrome, and granulomatous with polyangiitis.
- Specific cases: 1 lupus with secondary APS and Sjögren's, 1 lupus and secondary APS, 2 primary APS, 1 lupus, 1 primary Sjögren's, 1 granulomatous with polyangiitis.
Conclusions:
- Rheumatological diseases are an important, often overlooked, cause of ischemic stroke in young adults.
- Accurate etiological diagnosis is vital for preventing recurrent ischemic events.
- Increased clinician awareness and timely rheumatology referrals are recommended.
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