Advances of LAPONITE®-based nanocarrier in drug delivery applications

The polymer nanocomposite delivery platform has drawn a surge in interest in recent years especially in the field of pharmaceutics. Here we present an overview of a LAPONITE®-based nanoparticle drug delivery system (NDDS) along with LAPONITE®'s physicochemical properties, drug encapsulation efficiency, and the factors influencing drug release, biodegradability, and stability. The underlying interaction and chemistry between LAPONITE®, polymer and drug has been comprehensively covered. We present evidence of various triggering factors, such as pH, temperature, light, and magnetic fields, that facilitate the release of drugs from LAPONITE® nanocarriers. Examples of the use of LAPONITE®-based nanocomposites in the delivery of several types of therapeutics (anticancer, antibiotic, and anti-inflammatory), macromolecules and proteins are highlighted as related to biomedical applications. Several recommendations are discussed, including the potential to develop multifunctional, stimuli-responsive LAPONITE® nanocarriers for smart and controlled delivery of drugs. Finally, we discuss future directions, emphasizing the potential of multifunctional, stimuli-responsive LAPONITE® nanocarriers to enable smart, controlled drug delivery, offering promising avenues for the treatment of chronic diseases.