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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
176
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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What is Monogastric Digestion?01:50

What is Monogastric Digestion?

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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Related Experiment Video

Updated: Sep 10, 2025

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Towards Microbiota-Targeted Interventions in Acute Pancreatitis: Evidence From Meta-Analysis and Mendelian

Anqi Yi1, Wenjie Zhang1, Yuqiao Sun1

  • 1Department of Hepatobiliary Surgery, Yanbian University Affiliated Hospital, Yanji, Jilin Province, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 21, 2025
PubMed
Summary

Gut dysbiosis significantly increases acute pancreatitis (AP) risk, with specific bacteria like Olsenella and Clostridium leptum linked to higher risk and Odoribacter to protection. Findings support microbiota-targeted AP interventions.

Keywords:
Mendelian randomizationacute pancreatitiscausal inferencegenetic associationgut microbiotainstrumental variablesmeta‐analysis

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Area of Science:

  • Microbiome research
  • Gastroenterology
  • Genetic epidemiology

Background:

  • Previous Mendelian randomization (MR) studies suggest a causal link between gut microbiota and acute pancreatitis (AP).
  • Existing research primarily focused on European populations, necessitating investigation in other ethnicities.

Purpose of the Study:

  • To systematically evaluate the association between gut microbiota and AP risk in East Asian populations using meta-analysis and bidirectional MR.
  • To identify specific gut microbial taxa causally associated with AP risk across diverse populations.

Main Methods:

  • Meta-analysis of 10 studies investigating gut dysbiosis and AP risk.
  • Bidirectional Mendelian randomization (MR) analysis using large-scale genome-wide association study data.

Main Results:

  • Meta-analysis confirmed gut dysbiosis significantly increases AP risk, with "other functional microbiota" having the largest impact.
  • MR analysis identified causal links between specific gut microbiota and AP in both European and East Asian cohorts.
  • Olsenella and Clostridium leptum showed increased AP risk, while Odoribacter demonstrated a protective effect.

Conclusions:

  • Gut microbiota alterations are consistently associated with AP risk across populations.
  • Findings support the development of microbiota-targeted therapies for managing acute pancreatitis.
  • Specific bacterial taxa represent potential therapeutic targets for AP prevention and treatment.