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Updated: Sep 10, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Unexpected Tellurohalogenation of Terminal N-Alkynyl (Alkenyl) Derivatives of 4-Functionalized Pyrazoles
Marianna V Povidaichyk1, Svitlana V Shishkina2,3, Eugeniy M Ostapchuk4
1Department of Uzhhorod national university, 3 Narodna Sq, Uzhhorod, Ukraine.
Abstract:
The efficient synthesis of terminal N-alkenyl and N-alkynyl derivatives of pyrazole-4-carboxylic acids and their methyl esters as substrates for studying electrophilic heterocyclization has been reported. The regiochemistry and stereoselectivity of the tellurium-induced heterocyclization of 1-pentynyl (butynyl, butenyl) substituted pyrazole-4-carboxylic acids and their methyl esters under the action of tellurium (IV) oxide in hydrohalic acid were determined. This electrophilic heterocyclization leads to the formation of tetrahydropyrazolo[1,2-a]pyridazinium and dihydropyrazolo[1,2-a]pyrazolium intramolecular salts, as confirmed by X-ray diffraction (XRD) and comprehensive spectral analysis.
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