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Cerebrospinal fluid penetration of moxalactam in ventriculostomy patients
Abstract:
The cerebrospinal fluid penetration of moxalactam was simultaneously investigated in three patients with presumed bacterial meningitis. When ratios of simultaneously drawn ventriculostomy to serum moxalactam levels of 1, 2, 3, and 4 h were examined, the penetration ratios were 7.8 +/- 2.4, 11.2 +/- 1.3, 14.2 +/- 2.5, and 15.0 +/- 4.9%, respectively. These ratios were not statistically different from the penetration of moxalactam calculated by the area under the concentration-time curve technique (8.97 +/- 1.89%).
Insights
Moxalactam cerebrospinal fluid penetration was studied in bacterial meningitis patients. Penetration ratios were consistent between ventriculostomy/serum levels and area under the concentration-time curve analysis.
Area of Science:
- Pharmacology
- Infectious Diseases
- Neurosurgery
Background:
- Bacterial meningitis requires effective antibiotic penetration into the central nervous system.
- Moxalactam is a third-generation cephalosporin with potential utility in treating bacterial meningitis.
Purpose of the Study:
- To investigate the cerebrospinal fluid penetration of moxalactam in patients with presumed bacterial meningitis.
Main Methods:
- Simultaneous measurement of moxalactam levels in ventriculostomy fluid and serum.
- Calculation of penetration ratios at various time points (1, 2, 3, and 4 hours).
- Comparison with penetration calculated using the area under the concentration-time curve (AUC) method.
Main Results:
- Cerebrospinal fluid penetration ratios at 1, 2, 3, and 4 hours were 7.8%, 11.2%, 14.2%, and 15.0%, respectively.
- These penetration ratios were not statistically different from the AUC-calculated penetration (8.97%).
Conclusions:
- Moxalactam demonstrates significant penetration into the cerebrospinal fluid in patients with bacterial meningitis.
- The study validates the use of ventriculostomy to serum level ratios for assessing antibiotic penetration.