Hotspots and future trends of male breast cancer: a global perspective

Male breast cancer (MBC), a rare disease accounting for less than 1% of all cancers in men and approximately 1% of all breast cancers globally, exhibits unique biological and clinical characteristics that distinguish it from female breast cancer (FBC). To identify the latest developments and trends in MBC research, we performed a comprehensive analysis of relevant literature and generated visual representations of the data. Building on these outcomes, we delve into the insights gained, aiming to enhance the ongoing comprehension of MBC.

We conducted a search of the Web of Science Core Collection (WoSCC) for English-language articles and reviews on MBC published from 1982 to 2024. Following a rigorous dual-researcher screening process, we refined the dataset to 6802 relevant records. Subsequently, we employed Microsoft Excel for initial data organization and processing. For in-depth analysis and visualization of journal, country/region, author/institution trends, as well as keyword patterns, we utilized a combination of R Package, VOSviewer, and CiteSpace. This multi-tool approach enabled us to extract and present meaningful insights from the data.

MBC research has risen since 1996, with a 2024 peak at 503 publications, reflecting advances like BRCA1/2 gene discoveries. The USA leads in publications and citations, with North America and Europe being the most collaborative regions. Key journals include Breast Cancer Research and Treatment, and leading contributors are Ottini, Laura and Van Diest, Paul J. Research focuses on MBC's genetic links (e.g. BRCA mutations) and clinical features, with emerging topics like precision medicine and immunotherapy.

MBC research has grown but remains concentrated in high-income countries. Future efforts should explore MBC's unique biology, improve diagnostic/therapeutic strategies, and involve global, interdisciplinary collaboration to enhance patient outcomes.