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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
67
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

157
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

382
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

55
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Related Experiment Video

Updated: Sep 10, 2025

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
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Predicting Chronic Kidney Disease After Cisplatin Treatment Using Population-Level Data.

Robert C Grant1,2,3, Jiang Chen He1,2, Ning Liu3

  • 1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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|August 21, 2025
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Summary

Cisplatin chemotherapy can cause kidney damage. A simple model using baseline kidney function (eGFR) effectively predicts chronic kidney disease (CKD) risk after treatment, aiding clinical decisions.

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Area of Science:

  • Nephrology
  • Oncology
  • Clinical Epidemiology

Background:

  • Cisplatin is a vital chemotherapy agent with known nephrotoxicity.
  • Chronic kidney disease (CKD) risk and predictability post-cisplatin are not well understood.
  • Early identification of at-risk patients is crucial for intervention.

Purpose of the Study:

  • To determine the incidence of CKD following cisplatin treatment.
  • To evaluate the effectiveness of prediction models for post-cisplatin CKD.
  • To identify key predictors of cisplatin-induced nephrotoxicity.

Main Methods:

  • A population-based prognostic study utilizing retrospective and prospective cohorts.
  • Development and validation of prediction models using demographics, clinical data, and patient-reported symptoms.
  • Analysis of estimated glomerular filtration rate (eGFR) to assess kidney function outcomes.

Main Results:

  • 13.6% of patients without pre-existing CKD developed CKD after cisplatin treatment.
  • A simple spline regression model using only pre-treatment eGFR accurately predicted CKD risk.
  • Complex machine learning models did not outperform the basic eGFR-based model.

Conclusions:

  • Cisplatin treatment leads to a predictable decline in kidney function.
  • Lower baseline eGFR is the primary risk factor for developing CKD post-cisplatin.
  • An eGFR-based prediction model can guide clinical management and personalize patient care.