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Updated: Sep 10, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record

Claudia Alvarez-Carreño1

  • 1Department of Structural and Molecular Biology, University College London, London, UK.

Genome Biology and Evolution
|August 21, 2025
PubMed
Summary

Protein structural motifs reveal evolutionary links between distinct folds. This study analyzes the beta-hammerhead motif to understand protein fold evolution and divergence.

Keywords:
circular permutationdomain swappingfold changeprotein evolutionprotein folding

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