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Updated: Sep 10, 2025

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Published on: September 20, 2020
Adverse Events in Targeted Radionuclide Therapy
Kip E Guja1, Joy Wu1, Harrison L Agordzo1
1From the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, 300 Pasteur Dr, Stanford, CA 94305 (K.E.G., J.W., H.R.N., E.G., J.S.); Division of Health Physics, Department of Environmental Health and Safety, Stanford University, Stanford, Calif (H.L.A., J.K., D.S.); and Department of Pediatric Radiology, Lucile Packard Children's Hospital at Stanford, Stanford, Calif (H.R.N.).
Abstract:
Targeted radionuclide therapy (TRT) plays an important role in management of oncology patients, particularly those with thyroid cancer, prostate cancer, or neuroendocrine tumor. Use of TRTs has expanded rapidly in recent years, with approval of new agents and indications. The number of ongoing TRT clinical trials suggests that this trend is likely to continue in the future. Adequate knowledge of potential adverse events and their management is essential for treating physicians to optimize outcomes in patients undergoing TRT. The authors review adverse events that may occur in TRT; their clinical manifestations, incidence, risk factors, and management; and strategies to prevent or decrease their risk of occurrence. ©RSNA, 2025.
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