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Targeted radionuclide therapy (TRT) is increasingly used for cancers like thyroid and prostate. Understanding and managing TRT

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Targeted radionuclide therapy (TRT) is a cornerstone in managing specific cancers, including thyroid, prostate, and neuroendocrine tumors.
  • The utilization and indications for TRT have seen significant expansion, supported by ongoing clinical trials.

Purpose of the Study:

  • To provide a comprehensive review of adverse events associated with targeted radionuclide therapy.
  • To detail the clinical manifestations, incidence, risk factors, and management strategies for TRT-related adverse events.
  • To outline preventive measures for minimizing the risk of adverse events in patients undergoing TRT.

Main Methods:

  • Systematic review of literature on adverse events in targeted radionuclide therapy.
  • Analysis of clinical manifestations, incidence rates, and identified risk factors.
  • Evaluation of current management and prevention strategies for TRT-induced toxicities.

Main Results:

  • TRT is associated with a spectrum of potential adverse events that require careful monitoring.
  • Risk factors and specific clinical presentations vary depending on the TRT agent and target.
  • Effective management and preventive strategies are crucial for optimizing patient outcomes.

Conclusions:

  • Physicians must possess adequate knowledge of TRT adverse events for optimal patient care.
  • Proactive management and risk mitigation are essential for the safe and effective application of TRT.
  • The expanding role of TRT necessitates continued research into its safety profile and management.