Related Experiment Video
Updated: Sep 10, 2025

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
Silicone oil removal-related vision loss
Maria Ludovica Ruggeri1, Mario R Romano2, Tommaso Rossi3
1Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, Chieti 66100, Italy.
None:
Silicone oil removal-related vision loss (SORVL) is a sight-threatening condition affecting a small fraction of patients after the removal of silicone oil, possibly underestimated. To date, a few cases have been thoroughly investigated; however, no clear and unique explanation has been found for this phenomenon. Most of the literature has been focusing on SORVL and in situ SORVL, gathering the 2 conditions under the same pathogenic mechanism. In this review, we provide a detailed update on SORVL describing its epidemiology and the reported signs and symptoms. Furthermore, we explore possible underlying mechanisms that may contribute to the development of SORVL giving insights into the pathophysiology of this rare and severe condition.
Related Concept Videos
Photoreceptors and Visual Pathways
Angle Closure Glaucoma: Treatment
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview

