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Lathyrane and jatrophane diterpenoids: Potential lipid-lowering agents from Euphorbia helioscopia L
Sheng Chen1, Wen-Zheng Zhao1, Zhi-Yan Zhang1
1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
Abstract:
Four new Euphorbia diterpenoids, helioranes A-C (1-3) and heliophane A (4), and six know analogues were isolated from the whole plants of Euphorbia helioscopia. Among them, compounds 1-3 are typical lathyranes varying with substituents, compound 4 is a rare 7,8-seco-jatrophane diterpenoid. The structures of the novel compounds were unequivocally established through an integrated approach combining spectroscopic analyses and quantum chemical calculations. Lipid-lowering activity screening in 3 T3-L1 cells demonstrated that compound 3 and 9 exhibited potential inhibitory effects on lipid accumulation.
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