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  11. Development Of Personalized Dexamethasone Orodispersible Solid Oral Dosage Forms By Semisolid Extrusion 3d Printing

Development of personalized dexamethasone orodispersible solid oral dosage forms by semisolid extrusion 3D printing

Nicola Paccione1, Victor Guarnizo-Herrero2, Arantza Navarro-Alvarez3

  • 1TECNALIA, Basque Research and Technology Alliance (BRTA), Leonardo Da Vinci 11, 01510 Miñano, Spain; Joint Research Laboratory (JRL) on Advanced Pharma Development, A Joint Venture of TECNALIA and University of the Basque Country, Centro de investigación Lascaray ikergunea, 01006 Vitoria-Gasteiz, Spain; NanoBioCel Group, Department of Pharmacy and Food Science, Faculty of Pharmacy, University of the Basque Country (UPV/ EHU), 01006 Vitoria-Gasteiz, Spain.

International Journal of Pharmaceutics
|August 21, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

This study developed 3D printed dexamethasone orodispersible dosage forms using safe excipients. The personalized printlets ensure rapid disintegration and uniform drug content, improving patient care.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
Keywords:
3D printingDrugOralOrodispersible

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  • Drug Delivery

    • Background:

    • Personalized medicine requires adaptable dosage forms.
    • Orodispersible dosage forms offer improved patient compliance, especially for pediatric and geriatric populations.
    • 3D printing enables customized drug manufacturing.

    Purpose of the Study:

    • To develop a 3D printable semisolid extrusion formulation for dexamethasone.
    • To create personalized orodispersible dosage forms with controlled drug release.
    • To ensure the manufactured dosage forms meet pharmacopoeial standards for quality and disintegration.

    Main Methods:

    • Optimization of 3D printing inks using generally regarded as safe excipients.
    • Formulation of dexamethasone-loaded printlets with varying doses (0.25 mg to 5 mg).
    • Evaluation of physical characteristics (surface area to volume ratio, weight) influencing disintegration time.
    • Assessment of disintegration time, dissolution, mass uniformity, and content uniformity.

    Main Results:

    • Printlets achieved disintegration within 3 minutes, meeting orodispersible criteria.
    • Surface area to volume ratio > 1.94 and maximum weight of 165.39 mg ensured orodispersibility.
    • All 9 tested designs met pharmacopoeial standards for mass and content uniformity.
    • Successful manufacturing of dexamethasone dosage forms with precise dosing.

    Conclusions:

    • Semisolid extrusion 3D printing is a viable method for producing personalized dexamethasone orodispersible dosage forms.
    • This approach allows for tailored therapeutic solutions, enhancing patient care, particularly for vulnerable groups.
    • The developed technology upholds drug manufacturing quality standards while offering customized treatment options.
    Personalised medicine
    Printlet
    Tablet