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Updated: Aug 12, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
Published on: December 26, 2016
[A Case of Liver and Axillary Lymph Node Metastasis 32 Years after Breast Cancer Surgery]
Ayaka Aikawa1, Masanori Oshi, Kei Kawashima
1Yokohama City University School of Medicine.
Abstract:
unknown, but she remained symptom-free for 32 years. However, a CT scan performed for an unrelated condition revealed 2 liver tumors with calcifications located in S8(10 cm)and S6(3 cm). Given her medical history, liver metastasis from breast cancer was suspected. Core needle biopsies of the liver tumor and a left axillary lymph node detected on PET-CT, confirmed metastatic breast cancer that was estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor 2-negative. Upon diagnosis, chemotherapy with paclitaxel and bevacizumab was initiated. Follow-up CT scans at 6 and 15 months showed continued tumor regression in the liver and axilla. After 15 months of treatment, both tumors continued to shrink. Although late recurrence is common with breast cancer, recurrence more than 30 years post-surgery is rare. This case of late-stage metastatic breast cancer is presented alongside a literature review.
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