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Updated: Sep 10, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic infiltration in gallbladder pathologies: A clinical dilemma
Hüseyin F Martlı1, Arzu H Aydın1, Eda Şahingöz1
1From the Department of Pathology (Aydın), Aksaray University, Aksaray Training and Research Hospital, Aksaray, from the Department of General Surgery (Şahingöz, Er, Akgül), and from the Department of Pathology (Turhan, Tez), Ankara City Hospital, Çankaya, Ankara, Turkey.
Eosinophilic cholecystitis (EC) is rare. This study found no distinct clinical signs, with diagnosis relying on pathology, though liver hydatid cysts were noted in some cases.
Area of Science:
- Gastroenterology
- Pathology
- Surgical Pathology
Background:
- Eosinophilic cholecystitis (EC) is an uncommon condition identified in cholecystectomy specimens.
- Understanding its clinicopathological features is crucial for accurate diagnosis.
Purpose of the Study:
- To determine the clinicopathological features and prevalence of Eosinophilic cholecystitis (EC).
- To investigate the association between EC and liver hydatid cysts.
Main Methods:
- Retrospective analysis of 8,342 cholecystectomy specimens.
- Confirmation and re-examination of 33 EC cases by pathologists.
- Collection of demographic, clinical, laboratory, radiological, and pathological data.
Main Results:
- The average age of EC patients was 47 years.
- EC was associated with acute cholecystitis (15.6%), chronic cholecystitis (75.8%), and cholelithiasis (9.1%).
- Five patients (15.1%) had concurrent liver hydatid cysts; no significant differences in eosinophil counts or gallbladder wall thickness were observed between patients with and without hydatid cysts.
Conclusions:
- Eosinophilic infiltration is part of inflammatory gallbladder processes.
- Liver hydatid cysts may be associated with EC.
- EC diagnosis is primarily pathological, lacking distinct clinical, laboratory, or radiological indicators.
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