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Related Experiment Video

Updated: Sep 10, 2025

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Predicting and preventing preterm birth in Europe: current challenges and gaps.

Gian Carlo Di Renzo1,2, José Luis Bartha3, Anna L David4

  • 1PREIS International School, Firenze, Italy.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|August 21, 2025
PubMed
Summary

Preterm birth (PTB) in Europe needs better prediction and prevention strategies. Current methods are insufficient, highlighting the need for new tools to improve maternal and neonatal outcomes and reduce healthcare costs.

Keywords:
Preterm birthneonatal morbidityneonatal mortalityprevention toolsrisk assessment

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Area of Science:

  • Perinatal medicine
  • Public health
  • Epidemiology

Background:

  • Preterm birth (PTB) is a major cause of infant mortality and morbidity in Europe.
  • Despite advances, PTB rates have seen limited decline, indicating gaps in current risk assessment and prevention strategies.

Purpose of the Study:

  • To review challenges and disparities in European PTB prediction and prevention.
  • To highlight the multifaceted risk factors contributing to PTB.

Main Methods:

  • Review of current literature on PTB prediction and prevention in Europe.
  • Analysis of maternal, fetal, environmental, and sociodemographic risk factors.

Main Results:

  • Existing PTB prediction tools have limited effectiveness due to the complexity and multifactorial nature of PTB.
  • While cervical length screening and biomarkers show promise, their implementation is inconsistent.
  • Effective interventions like progesterone therapy and low-dose aspirin lack standardized application and require region-specific approaches.

Conclusions:

  • Addressing the persistent PTB burden requires unified guidelines, optimized interventions, and novel risk assessment tools.
  • Public health policies must target modifiable risk factors pre- and post-conception.
  • Improved strategies are essential for maternal and neonatal well-being and reduced long-term costs.