Clinical Application of 3D-Printed Custom Hemipelvic Prostheses With Re-Entrant Chiral Structure in Reconstruction...

Area of Science:

• Orthopedic oncology
• Biomaterials engineering
• Reconstructive surgery

Background:

• Conventional 3D-printed prostheses for pelvic reconstruction face a trade-off between porosity for bone ingrowth and mechanical stability.
• Novel designs are needed to optimize both osseointegration and structural integrity.

Purpose of the Study:

• To evaluate the clinical outcomes of 3D-printed hemipelvic prostheses incorporating a re-entrant chiral structure (RCS) in patients undergoing pelvic reconstruction post-tumor resection.
• To assess the balance between mechanical stability and biological integration offered by RCS prostheses.

Main Methods:

• Retrospective analysis of 15 patients with pelvic malignancies who received RCS 3D-printed hemipelvic prostheses.
• Evaluation included oncological status, functional performance (MSTS-93), pain (VAS), surgical parameters, complications, and radiographic analysis.
• Follow-up duration averaged 44.5 months.

Main Results:

• 86.7% of patients remained disease-free; significant improvements in MSTS-93 scores (14.5 to 25.8, p<0.001) and VAS pain scores (5.5 to 1.5, p<0.001) were observed.
• No mechanical failures, loosening, or fractures occurred.
• Radiographic analysis confirmed progressive bone ingrowth into RCS regions without osteolysis or migration.

Conclusions:

• 3D-printed hemipelvic prostheses with RCS provide an effective solution for pelvic reconstruction.
• The RCS design achieves an optimal balance between mechanical stability and biological integration.
• Promising clinical outcomes support the use of RCS in complex reconstructive surgery.