Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells.

Frontiers in immunology·2025

Same author

Opto-APCs: Displaying Phytochrome B on the Surface of Living Cells for Optogenetic Studies.

Methods in molecular biology (Clifton, N.J.)·2025

Same author

Coupling Recombinant PhyB to Cell Culture Plates and Beads.

Methods in molecular biology (Clifton, N.J.)·2025

Same author

Development of a Peptide Inhibitor Targeting the C-SH2 Domain of the SHP2 Phosphatase.

Chembiochem : a European journal of chemical biology·2025

Same author

Allosteric Changes Underlie the Outside-In Transmission of Activatory Signals in the TCR.

Immunological reviews·2025

Same author

From TCR fundamental research to innovative chimeric antigen receptor design.

Nature reviews. Immunology·2024

Search research articles

Related Experiment Video

Updated: Sep 10, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

Sabotaging TCR signaling-LAG3 interferes with the CD3ε-LCK interaction

Gina J Fiala¹, Wolfgang W Schamel^2,3

¹Signalling Research Centres BIOSS and CIBSS, and Department of Immunology, Insitute of Biology III, Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.

|August 21, 2025

Summary

No abstract available in PubMed .

More Related Videos

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Related Experiment Videos

Last Updated: Sep 10, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019