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DNA Sequence Perplexity Reveals Evolutionarily Conserved Patterns in cis-Regulatory Regions Across Diverse Species

Aruna Sesha Chandrika Gummadi1, Venkata Rajesh Yella2

  • 1Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522302, India.

Biochemical Genetics
|August 21, 2025
PubMed
Summary

We introduce DNA sequence perplexity, an information-theoretic metric, to identify cis-regulatory regions across species. Lower perplexity in these regions suggests conserved, evolutionarily stable patterns in DNA regulation.

Keywords:
Cis-regulatory regionDNA sequence perplexityPromoterShannon entropy

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