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Comparison of the Efficacy of Different Exercise Modes on MCI Adults: A Network Meta-Analysis
Changjiang Qiu1,2, Jiaxin Han1,2, Yao Xie3
1Hunan University of Chinese Medicine, Changsha, China.
Background:
Mild cognitive impairment (MCI) is considered a preclinical or prodromal stage of Alzheimer's disease (AD). MCI patients have an annual probability of progression to dementia of 10%-15%, far higher than the normal elderly (∼1%-2%). We conducted a network meta-analysis (NMA) on the efficacy of various exercise modes on MCI adults.
Methods:
A computer search was conducted in Embase, PubMed, the Cochrane Library, and Web of Science for RCTs on the effects of exercise training on MCI patients from their inception to February 22, 2025. Two reviewers were independently responsible for study screening, data extraction, and quality assessment. RevMan 5.4, Stata15, and R4.4.1 were utilized for data analysis.
Results:
Thirty-five studies with 2717 patients were included. The NMA results revealed that combination training (CT) performed best in increasing the MoCA and MMSE scores of MCI patients, with SUCRA of 99.43% and 87.04%, respectively. Resistance training and sensorimotor training were the second-best interventions for increasing MMSE and MoCA scores, respectively.
Conclusion:
CT is the best intervention to improve MOCA and MMSE scores in patients with MCI, which can effectively alleviate the disease progression of MCI. However, a variety of double-blind, large-sample clinical trials are still needed to further verify this conclusion.
Insights
Combination training is the most effective exercise for improving cognitive function in individuals with mild cognitive impairment (MCI). This approach significantly boosts scores on the MoCA and MMSE tests, potentially slowing disease progression.
Area of Science:
- Neurology
- Gerontology
- Exercise Science
Background:
- Mild cognitive impairment (MCI) represents a preclinical stage of Alzheimer's disease (AD).
- MCI patients exhibit a significantly higher annual progression rate to dementia (10%-15%) compared to the general elderly population (1%-2%).
Purpose of the Study:
- To evaluate the efficacy of different exercise modalities in improving cognitive function among adults with MCI.
- To conduct a network meta-analysis (NMA) comparing various exercise interventions for MCI.
Main Methods:
- A comprehensive literature search was performed across Embase, PubMed, Cochrane Library, and Web of Science for relevant randomized controlled trials (RCTs).
- Data extraction and quality assessment were conducted independently by two reviewers.
- Statistical analysis was performed using RevMan 5.4, Stata 15, and R 4.4.1.
Main Results:
- The network meta-analysis included 35 studies involving 2717 participants.
- Combination training (CT) demonstrated the greatest improvement in Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores for MCI patients.
- Resistance training and sensorimotor training were identified as the next most effective interventions for enhancing MMSE and MoCA scores, respectively.
Conclusions:
- Combination training is the optimal exercise intervention for enhancing MoCA and MMSE scores in MCI patients.
- Exercise, particularly combination training, shows potential in mitigating the progression of MCI.
- Further large-scale, double-blind clinical trials are warranted to validate these findings.
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