Related Experiment Video
Updated: Sep 10, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
The impact of exercise on prostate-specific antigen and testosterone in prostate cancer: a systematic review and
Fuxun Zhang1, Zhirong Luo1, Qi Xue1
1Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Background:
Exercise prescription can promote the rehabilitation of patients with prostate cancer (PCa). However, the effect of exercise intervention onserum levels of prostate-specific antigen (PSA) and testosterone remains unclear.
Methods:
The primary outcome was the effect of exercise prescription on PSA level. The secondary outcome was the effect of exercise training on testosterone level. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was selected as the indicator. Meta-regression was conducted to assess the relationship between covariates and outcomes. Publication bias was evaluated using funnel plots and Egger's test.
Results:
The data of 594 patients from 8 randomized controlled trials (RCTs) were included and analyzed. Pooled effect of exercise intervention on PSA was 0.13 (95% CI: -0.04 to 0.29, I2 = 0.0%, p = 0.984), while the pooled effect on testosterone was 0.19 (95% CI: -0.00 to 0.39, I2 = 0.0%, p = 0.435). The meta-regression showed there was no significant association of age, body mass index, and the exercise duration with PSA or testosterone. No significant publication bias was detected in meta-analysis.
Conclusions:
Although many benefits were documented, exercise intervention have no significant effect on PSA and testosterone levels in PCa patients.
Related Concept Videos
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Cancer Prevention
Some...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

