Related Experiment Video
Updated: Sep 10, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Scrambler therapy for chemotherapy-induced peripheral neuropathy: A case report
Zhu Wang1, Michael Carducci2, Giuseppe Marineo3
1Section of Palliative Medicine, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA.
Scrambler Therapy (ST) significantly reduced pain and improved function in a patient with chemotherapy-induced peripheral neuropathy (CIPN). Benefits were sustained long-term, suggesting ST as a promising alternative for CIPN management.
Area of Science:
- Neurology
- Oncology
- Pain Management
Background:
- Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, debilitating side effect of cancer treatment.
- Existing pharmacological treatments for CIPN often lack efficacy or are poorly tolerated.
- Scrambler Therapy (ST), a non-invasive neuromodulation technique, shows promise for neuropathic pain, but optimal protocols are unknown.
Purpose of the Study:
- To evaluate the effectiveness of Scrambler Therapy in alleviating pain and enhancing functional status in a patient with CIPN.
- To assess the impact of ST on symptom relief and daily functioning in a single-case study.
Main Methods:
- A single patient diagnosed with CIPN underwent a series of Scrambler Therapy sessions.
- Standardized assessment tools were employed to measure pain levels and functional status pre-therapy, during therapy, and post-therapy.
Main Results:
- The patient experienced significant reductions in pain intensity following ST treatment.
- Notable improvements in functional status were observed and sustained for several weeks to months post-therapy.
- These findings suggest potential long-term benefits of ST for managing CIPN symptoms.
Conclusions:
- Scrambler Therapy demonstrates potential as an effective, non-invasive treatment for reducing pain and improving function in CIPN patients.
- ST may offer a viable alternative to conventional treatments for managing neuropathic pain in oncology patients.
- Further research into optimal ST dosing regimens is warranted.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Treatment Resistant Cancers
Peripheral Artery Disease IV: Nursing Management
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...

