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Updated: Jul 10, 2026

Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
Moderate-intensity aerobic exercise attenuates obesity-induced changes in perivascular adipose tissue in female mice
Teresa M Da-Re1, Guilherme A Dos Santos1, Luiza H Rossi1
1Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Abstract:
The goal of the study was to investigate the effects of aerobic exercise training on inflammatory, oxidative stress, and cellular senescence biomarkers, along with the evaluation of morphology and anti-contractile response of perivascular adipose tissue of the thoracic aorta (tPVAT) in female mice (C57BL6/JUnib) divided into sedentary (SD), trained (TR), obese sedentary (OB-SD), and obese trained (OB-TR). In the OB-SD group, serum glucose, leptin, TNF-α, and malondialdehyde were increased, linked with enlarged lipid droplets, decreased adiponectin content in tPVAT, and enhanced vascular β-galactosidase activity accompanied by alterations in the anti-contractile response of tPVAT to serotonin (5-HT) compared with the SD group. Aerobic exercise training was effective in reducing serum leptin, TNF-α, and malondialdehyde in the OB-TR group, with smaller lipid droplets and increased adiponectin in the tPVAT, and attenuation of vascular β-galactosidase activity with beneficial effects in the vascular response to 5-HT. This study highlights a significant phenotypic change of the tPVAT in obese female mice with increased vascular senescence and dysregulation of the anti-contractile response, systemic inflammation, and oxidative stress. Aerobic exercise training effectively mitigated some of the obesity-induced changes in the tPVAT, partially restoring the anti-contractile response to 5-HT and reducing circulatory leptin, TNF-α, and malondialdehyde.
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