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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Iridium-catalyzed asymmetric reductive amination of C2-acylpyridines
Gang Wang1, Zhiwen Nie2,3, Hengzhi You1,2
1School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. youhengzhi@hit.edu.cn.
Abstract:
Chiral 1-pyridin-2-yl-ethylamines are significant building blocks for synthetic chemistry and pharmaceutical sciences, while their stereoselective and practical synthesis remains challenging and usually troublesome. Herein, we present a novel iridium-catalyzed direct asymmetric reductive amination of 2-acylpyridines with anilines, affording a series of chiral 1-pyridin-2-yl-ethylamines with up to 97% yield and 95% ee. A 5 mmol scale reaction is also performed to demonstrate the practicality of this method.
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