Related Experiment Video
Updated: Sep 10, 2025
06:06
Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
2.6K
Effects of Periodontal Therapy on Cardiovascular Risk Biomarkers: A Systematic Review
Oral Health & Preventive Dentistry
|August 22, 2025
Summary
Non-surgical periodontal therapy (NSPT) improves cardiovascular risk biomarkers, notably reducing inflammation and improving glycemic control in patients with or without diabetes. These findings support integrating periodontal care into cardiovascular risk management strategies.
Area of Science:
- Periodontology and Cardiology
- Systemic Inflammation and Chronic Disease
Background:
- Periodontal disease and cardiovascular disease share common inflammatory pathways.
- Bacterial translocation from the oral cavity contributes to systemic inflammation.
Purpose of the Study:
- To systematically review the impact of non-surgical periodontal therapy (NSPT) on cardiovascular risk biomarkers.
- To assess effects on endothelial function, systemic inflammation, thrombosis, and lipid/glucose metabolism.
Main Methods:
- Systematic search of PubMed, Cochrane Library, and Scopus databases (post-2010).
- Included adult patients with moderate-to-severe periodontitis treated with NSPT.
- Risk of bias assessment conducted for all studies.
Main Results:
- NSPT significantly reduced high-sensitivity C-reactive protein (hs-CRP) and inflammatory cytokines (IL-6, TNF-α).
- HbA1c levels decreased, especially in patients with type 2 diabetes.
- Endothelial function improved, with reduced endothelial microparticles (EMPs); vascular parameter results were heterogeneous.
Conclusions:
- NSPT demonstrates clinical relevance by improving inflammation and glycemic control.
- Findings support integrating periodontal care into cardiovascular risk management.
- Further research is needed for lipid metabolism and vascular function effects.
Related Concept Videos
01:26Atherosclerosis III: Management
33
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
33
01:30Coronary Artery Disease I: Introduction
55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
334
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
334
01:27Peripheral Artery Disease III: Interprofessional Care
29
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
29
01:23Assessment of the Cardiovascular System I: Subjective Data
467
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
467