Pulmonary diffuse large B-cell lymphoma with concurrent organizing pneumonia: a case report

Area of Science:

• Pulmonology
• Oncology
• Pathology

Background:

• Primary pulmonary lymphoma is a rare extranodal non-Hodgkin lymphoma.
• It often presents with atypical features, complicating diagnosis.

Observation:

• A 56-year-old female presented with recurrent fever and pulmonary lesions on CT.
• Initial diagnosis suggested organizing pneumonia, with temporary improvement on steroids.
• Recurrence and progression led to further investigation, revealing diffuse large B-cell lymphoma (DLBCL).

Findings:

• The case documents a rare coexistence of primary pulmonary DLBCL and organizing pneumonia.
• Diagnostic challenges included initial misdiagnosis and the need for repeat procedures.
• Treatment with R-CHOP chemotherapy showed a partial radiographic response.

Implications:

• This case underscores the importance of considering malignancy in atypical pulmonary presentations.
• It highlights the diagnostic difficulties and the need for thorough investigation.
• Understanding this coexistence is crucial for effective therapeutic strategies in pulmonary lymphomas.