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[Effect of desaminoocta-pancreozymin on the locomotor activity of rats]
Biomedica Biochimica Acta
|January 1, 1985
Abstract:
The influence of desaminoocta-pancreozymin (DAO-PZ) was investigated in high and low activity periods by intraperitoneal or intranasal application. DAO-PZ is a CCK-8 derivative in which the N-terminal amino acid (Asp) is exchanged for succinyl acid. A decreasing long lasting effect for 3 to 4 h was always observed in locomotor activity. A food reduction was also proved after i. p. and intranasal application. The effects correspond to those of CCK-8 reported in the literature. They are discussed in this respect.