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Updated: Sep 10, 2025
Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Usefulness of A Random Spot Urine Proteins-to-Creatinine Ratio to Screen for Increased Albuminuria in Patients with
El Hadji Malick Ndour1, Rokhaya Dione1, Fatou Gueye-Tall1
1Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
Background:
Moderately increased albuminuria is a biomarker for early onset diabetic nephropathy. The aim of this study was to evaluate the performance of use proteinuria-to-creatininuria ratio (UPCR) at different cut-off to screen for increased albuminuria using albuminuria-to-creatininuria ratio (UACR) as a gold standard.
Methods:
This was a cross-sectional study. A random spot urine sample was collected from patients with type 1 diabetes to measure albuminuria and total proteinuria using respectively an immunoturbidimetric and a colorimetric assay. Albuminuria was expressed as UACR and proteinuria as UPCR. The area under the curve (AUC) method and the kappa coefficient were used to compare UPCR and UACR.
Results:
In 150 diabetic patients, moderately increased albuminuria was detected in 33.3% using UACR and 35.3% using UPCR at 272 mg/g. UPCR thresholds of 130, 150, 180 and 200 mg/g yielded higher detection rates than UACR. However, all UPCR cut-offs showed low diagnostic accuracy (AUC < 70%), and agreement with UACR was mild (kappa < 0.40).
Conclusions:
The level of agreement between UPCR and UACR was moderate. It is not sufficient for UPCR to replace UACR to screen for increased albuminuria in patient with type 1 diabetes.
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