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Updated: May 8, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Hemorrhagic brain metastasis as the initial presentation of osteosarcoma: a rare case report
Salma El Aouadi1, Rania Bouanane1, Soukaina Bahha1
1Department of Radiology, National Institute of Oncology, Ibn Sina University Hospital Center, Avenue Allal El Fassi, Quartier des Orangers, Rabat 10000, Rabat-Salé-Kénitra Region, Morocco.
Abstract:
Osteosarcoma is the most common malignant bone tumor in children and adolescents, with a predilection for long bones and frequent pulmonary metastases. Brain metastases are rare, occurring in 1.8% to 5.6% of cases, and hemorrhagic ones are exceptionally uncommon, with only a few cases documented in the literature. We report the case of a 16-year-old girl who presented with acute headache and seizures. Imaging revealed hemorrhagic brain and pulmonary metastases, and biopsy confirmed a primary femoral osteosarcoma. This case represents an exceptionally rare presentation of osteosarcoma and highlights its aggressive metastatic behavior.
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