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Diffuse bilateral cerebral calcification caused by Vein of Galen aneurysmal malformation in a two-year-old child: A

Yenewub Muluken Tesfaye1, Daniel Zewdneh Solomon1, Yeabsira Feleke Lakew1

  • 1Department of radiology, college of health science, Addis Ababa University, Addis Ababa, Ethiopia.

Radiology Case Reports
|August 22, 2025
PubMed

Insights

Vein of Galen aneurysmal malformation, a rare cause of intracranial calcification in young children, can lead to developmental delay and seizures. This condition should be considered in pediatric cases of diffuse cerebral calcification.

Area of Science:

  • Pediatric Neurology
  • Neuroradiology
  • Medical Genetics

Background:

  • Intracranial calcification in children under 6 is typically pathological.
  • Congenital causes include arteriovenous malformations, infections, and neoplasms.

Observation:

  • A 2-year-old boy presented with developmental delay, seizures, and hydrocephalus.
  • Imaging revealed bilateral diffuse cerebral dystrophic calcification.

Findings:

  • The patient's symptoms and calcification pattern were consistent with an untreated Vein of Galen aneurysmal malformation.
  • This malformation causes chronic venous ischemia, leading to dystrophic calcification.

Implications:

  • Vein of Galen aneurysmal malformation is a rare but critical differential diagnosis for diffuse intracranial calcification in children.
  • Consideration of this diagnosis is important after excluding TORCH infections.

Keywords:
Intracranial calcificationIntracranial vascular malformationMalformationVein of Galen aneurysmal malformation

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