Interactions between tumor microenvironment and resistance to transarterial and systemic treatments for HCC
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View abstract on PubMed
Summary
This summary is machine-generated.Hepatocellular carcinoma (HCC) is a deadly liver cancer. Targeting the tumor microenvironment (TME) and modulating immune responses show promise for improving patient outcomes and overcoming treatment resistance.
Area Of Science
- Oncology
- Immunology
- Gastroenterology
Background
- Hepatocellular carcinoma (HCC) is a primary liver cancer often arising from chronic inflammation and fibrosis.
- Cirrhosis is the main risk factor for HCC, emphasizing the need for early detection.
- Despite treatment advances, HCC survival rates remain low, highlighting unmet clinical needs.
Purpose Of The Study
- To review the critical role of the tumor microenvironment (TME) in HCC development and progression.
- To explore how the TME influences immune evasion and therapeutic resistance in HCC.
- To discuss current and emerging strategies for targeting the TME to improve HCC treatment efficacy.
Main Methods
- Literature review of studies on HCC, tumor microenvironment, and immunotherapy.
- Analysis of the cellular and molecular components of the HCC TME.
- Synthesis of evidence on therapeutic strategies targeting the TME.
Main Results
- The TME comprises immune cells, fibroblasts, and extracellular matrix, significantly impacting tumor behavior.
- Specific immune cells within the TME promote immune suppression and HCC progression.
- Targeting the TME, particularly through immune modulation, demonstrates potential to enhance treatment response.
Conclusions
- The TME plays a pivotal role in HCC pathogenesis, immune evasion, and therapy resistance.
- Immune modulation strategies targeting the TME represent a promising therapeutic avenue for HCC.
- Combination therapies involving TME modulation may improve clinical outcomes for HCC patients.
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