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Blood microbial DNA signature differentiates hepatocellular carcinoma from metastatic lesions

Caitlin Guccione1,2,3, Ana Carolina Dantas Machado4, Fady Youssef4,5

  • 1Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA.

Egastroenterology
|August 22, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Carcinoma, HepatocellularCell-Free Nucleic AcidsColorectal NeoplasmsDigestive System NeoplasmsGastrointestinal CancerLiver NeoplasmsMicrobiotaNeoplasm Metastasis

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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