Related Experiment Video
Updated: Sep 10, 2025
Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Early healing after regenerative periodontal surgery with or without antibiotics
Ewa Dolińska1, Małgorzata Pietruska1, Robert Milewski2
1Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland.
Background:
The effectiveness of guided tissue regeneration (GTR) has been thoroughly documented. Since most post-GTR complications are related to the exposure of the membrane and its subsequent bacterial contamination, clinicians treat the incorporation of systemic antibiotics as an integral component of the standard surgical procedure. However, this approach remains controversial.
Objectives:
The aim of the study was to assess the effect of postsurgical administration of antibiotics on early healing and patient morbidity after treatment of periodontal intrabony defects with deproteinized bovine bone mineral (DBBM) and a collagen membrane (GTR).
Material And Methods:
The study encompassed 41 patients with 41 intrabony defects. The subjects were randomly assigned to either the test group (DBBM/GTR+AB (postsurgical antibiotic)) or the control group (DBBM/GTR). In the test group, 1 g of amoxicillin was administered twice daily for 7 days. The early healing index (EHI) was assessed 1 and 2 weeks after the procedure. Patient morbidity was recorded. The clinical attachment level (CAL), probing depth (PD) and gingival recession (GR) were measured at baseline and 6 months after surgery.
Results:
Early healing was uneventful in both groups. No adverse events were recorded in either group. In the second week, EHI-defined primary flap closure was evident in 95% of the test group sites and 80% of the control group sites. The CAL changed significantly in both groups: from 8.7 ±1.4 mm to 4.6 ±1.7 mm in the DBBM/GTR+AB group (p < 0.0001); and from 8.6 ±1.9 mm to 5.7 ±1.2 mm in the DBBM/GTR group (p < 0.0001). The significant outcome was in favor of the test group (p = 0.010). Probing depth significantly decreased in both groups, without any observed intergroup differences.
Conclusions:
The administration of systemic amoxicillin after regenerative periodontal surgery did not have any effect on early wound healing; however, it yielded a statistically significant CAL gain after 6 months compared to the group treated without antibiotics.
Related Concept Videos
01:26Tonsillitis II: Management
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
01:19Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
01:28Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
01:30Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...