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Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
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Cardiotoxicity in Breast Cancer Therapy: Risks, Mechanisms, and Prevention Strategies
Annisa Eka Fitrianti1,2, Nadea Olyvia Wardani1, Astri Astuti3
1Master's Program in Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, Indonesia.
Medical Sciences (Basel, Switzerland)
|August 22, 2025
Summary
Breast cancer treatments like anthracyclines and trastuzumab can cause heart damage. Cardioprotective strategies can help prevent or treat this cardiotoxicity, improving patient quality of life.
Area of Science:
- Oncology
- Cardiology
- Pharmacology
Background:
- Breast cancer is the most common cancer in women.
- Anthracyclines and trastuzumab are standard first-line treatments.
- These therapies can lead to cardiotoxicity, impacting quality of life and treatment adherence.
Purpose of the Study:
- To review risk factors and mechanisms of chemotherapy-induced cardiotoxicity in breast cancer.
- To explore effective prevention and treatment strategies for cardiotoxicity.
Main Methods:
- Literature review of studies on breast cancer treatment and cardiotoxicity.
- Analysis of risk factors, biological mechanisms, and cardioprotective interventions.
Main Results:
- Cardiotoxicity from anthracyclines is dose-dependent and often irreversible.
- Trastuzumab-associated cardiac dysfunction may be reversible.
- Several cardioprotective agents, including ACE inhibitors, ARBs, beta-blockers, and dexrazoxane, can mitigate cardiotoxic effects.
Conclusions:
- Understanding cardiotoxicity mechanisms is crucial for breast cancer management.
- Cardioprotective strategies can optimize cancer treatment while preserving cardiovascular function.
- Proactive management of cardiotoxicity is essential for patient well-being and treatment success.
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