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Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...

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Updated: Sep 10, 2025

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Comprehensive Fertility Management After Pituitary Adenoma Surgery: Lessons from a Rural Japanese Case and Practical

Daisuke Numahata^1,2, Kosuke Kojo^1,3, San-E Ishikawa^4,5

¹Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara, Tochigi 329-2763, Japan.

|August 22, 2025

Summary

This summary is machine-generated.

Pituitary adenomas can cause hypogonadotropic hypogonadism (HH) after surgery. Effective hormone therapy restored fertility and sexual function in a young patient, leading to a healthy child.

Keywords:

CNS tumor PitNET benign brain tumor central nervous system fertility preservation male infertility counseling oncofertility care network reproductive endocrinology sexual complications of neurosurgery sperm cryopreservation

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Area of Science:

Neuroendocrinology
Oncology
Reproductive Medicine

Background:

Pituitary adenomas (pituitary neuroendocrine tumors) can lead to hypogonadotropic hypogonadism (HH) post-surgery.
HH significantly impacts fertility and sexual function, especially in young patients.

Observation:

A 29-year-old man developed severe HH and azoospermia after two pituitary adenoma resections.
Fertility management was delayed due to lack of on-site endocrinology and oncofertility resources.

Findings:

Hormone therapy with human chorionic gonadotropin and recombinant follicle-stimulating hormone led to full recovery of sexual function.
Semen parameters normalized, resulting in spontaneous conception and a healthy birth.

Implications:

Early interdisciplinary collaboration and preoperative counseling are crucial for fertility preservation.
Integrating fertility considerations into preoperative counseling, even for benign tumors, is essential.
Strengthening oncofertility networks and provider awareness can improve patient outcomes.